Forvisirvat (SP-624)
SIRT6 is Foundational for Longevity and Metabolic Health
Over 800 papers in the literature support the importance of SIRT6 in health span
THE COMPOUND
SP-624 is a SIRT6 activator which has an epigenetic mechanism of action. SIRT6 is a gene silencer, that is believed to play a role in DNA repair, mitochondrial health, inflammation and glucose homeostasis.
RELEVANT PUBLICATIONS
- A phase 2, multicenter, double-blind, randomized, placebo-controlled study of the safety and efficacy of forvisirvat (SP-624) in the treatment of adults with major depressive disorder
- Phase 1, Single-Center, Double-Blind, Randomized, Placebo-Controlled Studies of the Safety,Tolerability, and Pharmacokinetics of Single and Multiple Ascending Oral Doses of the Sirtuin 6 Activator SP-624 in Healthy Adults
- Aging epigenome begins to change in age-related neurodegenerative diseases
- SIRT6 is a key regulator of mitochondrial function in the brain
- Restoration of energy homeostasis by SIRT6 extends healthy lifespan
- Sirtuin 6: linking longevity with genome and epigenome stability
- Complex role of SIRT6 in NF-kB pathway regulation
- Opposite molecular signatures of depression in men and women
